While other professions are concerned with changing the environment to suit the weakened body, chiropractic is concerned with strengthening the body to suit the environment.
— B. J. Palmer, DC

 IMMUNE HEALTH & CHIROPRACTIC

1) UNDER POOR MECHANICAL LOADING, CELLS WILL PREPARE FOR DEATH, INCREASES INFLAMMATION

Wang, J. H., & Li, B. (2010). Mechanics rules cell biology. Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT2, 16. doi:10.1186/1758-2555-2-16 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912251/

2) Chiropractic BOOSTS FUNCTION OF THE IMMUNE SYSTEM

Neil J. Manipulative therapy and immune response: A literature review of the chiropractic and osteopathic evidence. Clinical Chiropractic 2012;15(3):186.

3) NEUROIMMUNOMODULATION - immune homeostasis is based on the reciprocal communication between the immune system and the nervous system executed by the actions of cytokines and neurotransmitters

Teodorczyk-Injeyan JA, et al. SMT reduces inflammatory cytokines but not substance P production in normal subjects. JMPT, 2006;29:14-21.

4) Significantly increased synthesis of immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies induced in cultures of peripheral blood mononuclear cells in subjects who received thoracic manipulation, particularly in those who had an associated cavitation. The paper concludes that antibody synthesis (IgG and IgM) induced by interleukin-2 can be, at least temporarily, increased after manipulation. Direct evidence that thoracic manipulation may influence interleukin-2 immune-regulated biological responses.

Teodorczyk-Injeyan, J. A., McGregor, M., Ruegg, R., & Injeyan, H. S. (2010). Interleukin 2-regulated in vitro antibody production following a single spinal manipulative treatment in normal subjects. Chiropractic & osteopathy18, 26. doi:10.1186/1746-1340-18-26 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945351/

5) The present study demonstrates that, the in vitro T lymphocyte response to a conventional mitogen (SPA), as measured by IL-2 synthesis, can become enhanced following SMT. Furthermore, within a period of time following the manipulative intervention, this effect may be independent of joint cavitation. Thus the results of this study suggest that, under certain physiological conditions, SMT might influence IL-2-regulated biological responses.

Teodorczyk-Injeyan, J. A., Injeyan, H. S., McGregor, M., Harris, G. M., & Ruegg, R. (2008). Enhancement of in vitro interleukin-2 production in normal subjects following a single spinal manipulative treatment. Chiropractic & osteopathy16, 5. doi:10.1186/1746-1340-16-5 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423359/

6) A total of 9 chiropractic lower back manipulations caused the mediators of inflammation to present a normalization response in individuals suffering from chronic low back pain.

Roy, R. A., Boucher, J. P., & Comtois, A. S. (2010). Inflammatory response following a short-term course of chiropractic treatment in subjects with and without chronic low back pain. Journal of chiropractic medicine9(3), 107–114. doi:10.1016/j.jcm.2010.06.002 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188345/

7)This study demonstrates the positive effect of OMT on sIgA levels in persons experiencing high stress. Results suggest that OMT may then have therapeutic preventive and protective effects on both healthy and hospitalized patients, especially those experiencing high levels of emotional or physiological stress and those at higher risk of acquiring upper respiratory tract infections. Boosts IgA antibody levels by 137%

J Am Osteopath Assoc. 2011 Mar;111(3):143-7. Impact of osteopathic manipulative treatment on secretory immunoglobulin a levels in a stressed population. Saggio G1,

8) Neuroimmunology – the past, present and future

Nutma, E., Willison, H., Martino, G., & Amor, S. (2019). Neuroimmunology - the past, present and future. Clinical and experimental immunology, 197(3), 278–293. doi:10.1111/cei.13279 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693969/

9) The autonomic nervous system and neuroimmune interactions

Kenney, M. J., & Ganta, C. K. (2014). Autonomic nervous system and immune system interactions. Comprehensive Physiology, 4(3), 1177–1200. doi:10.1002/cphy.c130051

10) Chiropractic adjustments were shown to increase phagocyte function.

Brennan P, Graham M, Triano J, Hondras M. "Enhanced phagocytic cell respiratory bursts induced by spinal manipulation: Potential Role of Substance P." J Manip Physiolog Ther 1991; (14)7:399-400.